Julio C. Velluti MD, PhD. Head lab Neural Integration

Currently my laboratory is constituted by my self and a pre-doctoral fellow financed by the Institute.
My research interests are related to the cellular basis of epileptogenesis. More specifically I correlate the intracellular cell activity and the cortical field potential in the simpler cerebral cortex of the turtle. Using field potential recording, I have found transient high voltage events similar to the mammalian interictal-epileptical spike. The experiment are performed in vitro, in a whole hemisphere preparation and also in conventional slices (400 to 2000 ?m thick) .
The field potentials are performed with thin wall glass micropipettes filled with Ringer solution.
The intracellular recording are both sharp and whole cell recording mode.

At this moment, I am studding the effect of the electrical synapses and other neurotrasmitters such as norepinephrine, dopamine and 5-HT in cortical electrogenesis.

Papers

-Capurro, A; Diambra, L; Lorenzo, D; Macadar, O; Martin, M; Mostaccio, C; Plastino, A; Rozman E; Torres, M; and Velluti , J.C.
Human brain dynamics: the analysis of EEG signals with Tsallis information measure. Physica A, vol. 265, 235.

-Lorenzo D, Macadar O, Velluti JC
Origin and propagation of spontaneous electrographic sharp waves in the in vitro turtle brain: a model of neuronal synchronization.
Clin Neurophysiol 110(9):1535-1544

-C. Silva-Barrat, M. Szente, Ch. Menini, J.C.Velluti and J. Champagnat.
Muscarinic depression of synaptic transmission in the epileptogenic GABA withdrawal syndrome focus.
J. Neurophysiol, 85: 2159-2165

-Noradrenaline decreases spike voltage threshold and induces electrographic sharp waves in turtle cortex.
Lorenzo D. and Velluti J.C. (aceptado para su publicación, Brain, Behaviour and Evolution).

-C. Silva-Barrat, J.C. Velluti, M. Szente and J. Champagnat.
Exaggeration of epileptic-like patterns by nicotinic receptor activation during GABA withdrawal syndrome.

Others.

Ex-Coordinator of the subarea of Neurociencia.
Ex-Member of the Commission of Doctorate PEDECIBA
Ex-Member of the Commission of Scientific research of the Medicine Faculty.